HDAC6 degrader 9c( dHDAC6 9c )

Catalog No. M13585 CAS No. 2235382-05-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

HDAC6 degrader 9c
Note

Research use only, not for human use.
Brief Description

HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand.
Description

HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand; causes degradation of HDAC6 in a dose dependent manner (DC50=34 nM), upregulate the level of acetylated α-tubulin at 1.1 uM; shows the maximal effect of HDAC6 degradation at 80 nM in the MM.1S cell line.
In Vitro

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In Vivo

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Synonyms

dHDAC6 9c
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

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Indication

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CAS Number

2235382-05-3
Formula Weight

775.82
Molecular Formula

C37H45N9O10
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(NO)CCCCCCC(N/N=C/C1=CC=C(OCCOCCOCCN2N=NC(CNC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O)=C2)C=C1)=O
Chemical Name

(E)-8-(2-(4-(2-(2-(2-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)benzylidene)hydrazinyl)-N-hydroxy-8-oxooctanamide

1. Tan S, et al. Bioorg Med Chem. 2017 Aug 1;25(15):4123-4132.

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